Continuing its track record of innovation, LMT is proud to announce that it has been selected for a 2017 Phase I SBIR award. In this Small Business Innovative Research (SBIR) effort, Leiden Measurement Technology LLC (LMT) will design and build the Wholly-integrated Optofluidic Laser-induced Fluorescence Electrophoresis Chip (WOLFEChip), a microchip capillary electrophoresis (MCE) system using a miniaturized optofluidic approach for packaging all optical elements necessary for laser-induced fluorescence (LIF) on-chip.
WOLFEChip uses cutting-edge laser micromachining to fabricate fully-three-dimensional optical elements that focus excitation laser light into a MCE microchannel to excite fluorescence. The fluorescence emission is collected using custom-designed high-numerical aperture collection optics immune to misalignment of the chip up to 1-mm. This improves on current and past implementations of MCE-LIF by greatly miniaturizing the optical elements; greatly enhancing the vibration-resistance of the entire system; making the system immune to operator-to-operator variations caused by the periodic need for realignment, and greatly reducing measured stray light.